A. Hoshino

This study identifies the Keap1-Nrf2 pathway as a regulator of TGF-β-mediated CTGF expression in fibroblasts, showing that Nrf2 with Ddx54 suppresses profibrotic genes and reduces fibrosis in mouse heart and kidney.

This paper introduces a freeze-drying and gaseous nitrogen-based method to improve SEM imaging while preserving fluorescent signals, enabling better visualization of cellular structures and TEV-host interactions.

This paper shows UNC-45A increases microtubule curvature and counteracts Taxol's straightening effects, suggesting a role in drug resistance.

The paper develops a DMS platform to analyze SARS-CoV-2 spike mutations, finding that spike expression, not ACE2 affinity, primarily affects infectivity and evolution.

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

This study uses deep mutational scanning to predict antibody escape in SARS-CoV-2 Omicron subvariants, identifying key mutations that confer resistance to bebtelovimab.

This study uses CRISPR/Cas9 screens to identify RARA and SPNS1 as genetic modifiers of doxorubicin cardiotoxicity, revealing their roles in cell death and drug accumulation.

This study identifies and classifies 126 R2R3-MYB genes in Japanese morning glory, linking their functions to Arabidopsis orthologs and suggesting roles in cell division, anthocyanin biosynthesis, and stress response.

This study identifies lipophagy as a therapeutic approach to prevent NASH progression by promoting lysosomal lipid exocytosis and reducing intracellular fatty acid accumulation.

This paper shows engineered ACE2 neutralizes Omicron and other sarbecoviruses effectively despite its high number of spike mutations.

The paper investigates GLS1 expression in ARID1A-mutated ovarian clear cell carcinoma and finds it is not correlated with ARID1A loss and is associated with better clinical outcomes.

The paper engineers high-affinity ACE2 receptors to neutralize SARS-CoV-2 in hamsters, showing protection against infection without viral escape mutations.

This study shows UNC-45A weakens and breaks microtubule lattices independently of its effect on non-muscle myosin II, with implications for disease treatment.

This study identifies endocytosis-related gene polymorphisms in breast cancer and suggests alpha-cyclodextrin as a potential treatment to inhibit metastasis and exosome packaging.