D. Lyden

Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach

This paper introduces a freeze-drying and gaseous nitrogen-based method to improve SEM imaging while preserving fluorescent signals, enabling better visualization of cellular structures and TEV-host interactions.

ERα-LBD, a novel isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

The paper identifies ER-LBD, a novel estrogen receptor alpha isoform, which promotes breast cancer growth and resistance to endocrine therapy.

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling

This study shows BRCA mutations in pancreatic cancer alter CAF subtypes, specifically increasing CLU+ CAFs, and links this to HSF1 signaling.

Cell-free DNA (cfDNA) and exosome profiling from a year-long humanspaceflight reveals circulating biomarkers

This study profiles cfDNA and exosomes from an astronaut during a year-long spaceflight, identifying increased cf-mtDNA and exosomal brain-derived peptides as potential biomarkers of spaceflight-related stress.

Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer

This study identifies endocytosis-related gene polymorphisms in breast cancer and suggests alpha-cyclodextrin as a potential treatment to inhibit metastasis and exosome packaging.