Author

C. Castillo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2

Frequent Co-Authors

Y. M. Shah· 3 shared A. Andren· 2 shared J. D. Mancias· 2 shared N. K. Das· 2 shared A. Balia· 1 shared A. Califano· 1 shared A. Curiel-Garcia· 1 shared A. Iuga· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

Y. M. Shah

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

S. L. DeAngelo, L. Zhao, S. Dziechciarz, M. Shin, S. Solanki, A. Balia, M. O. El-Derany, C. Castillo, Y. Qin, N. K. Das, H. N. Bell, J. A. Paulo, Y. Zhang, N. J. Rossiter, E. C. McCulla, , Y. M. Shah

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

bioRxiv · Mar 29, 2024 · PreprintCancer Biology

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

A. Curiel-Garcia, S. Holmstrom, C. Castillo, C. F. Palermo, S. A. Sastra, A. Andren, L. Tomassoni, Z. Li, T. LeLarge, I. Sagalovskiy, D. R. Ross, W. Wong, K. Shaw, J. Genkinger, H. Hibshoosh, , K. P. Olive

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

bioRxiv · Mar 19, 2023 · PreprintCancer Biology

PINK1 supports colorectal cancer growth by regulating the labile iron pool.

B. Chen, N. K. Das, I. Talukdar, R. Singhal, C. Castillo, A. Andren, J. D. Mancias, C. A. Lyssiotis, Y. M. Shah

This study shows PINK1 supports colorectal cancer growth by regulating the labile iron pool through mitophagy and ferritinophagy.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation through N-formyl peptide receptor 2 in a chronic murine model of Chagas disease

I. Carrillo, R. Rabelo, C. Barbosa, M. Rates, S. Fuentes-Retamal, F. Gonzalez-Herrera, D. Guzman-Rivera, H. Quintero, U. Kemmerling, C. Castillo, F. S. Machado, G. Diaz-Araya, J. D. Maya

This study shows that AT-RvD1 reduces cardiac inflammation and parasite load in a chronic Chagas disease model by acting through FPR2.

bioRxiv · Aug 17, 2021Microbiology

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

V. Miguel, J. Tituana, J. I. Herrero, L. Herrero, D. Serra, P. Cuevas, C. Barbas, D. Rodriguez-Puyol, L. Marquez-Exposito, M. Ruiz-Ortega, C. Castillo, X. Sheng, K. Susztak, M. Ruiz-Canela, J. Salas-Salvado, , S. Lamas

This study shows that overexpressing Cpt1a in renal tubular epithelial cells reduces fibrosis by restoring mitochondrial function and bioenergetics in CKD models and human patients.

bioRxiv · Feb 18, 2020Biochemistry

Imaging The Electrical Activity Of Organelles In Living Cells

E. Matamala, C. Castillo, J. P. Vivar-Casas, S. E. Brauchi

The paper introduces hVoSorg, an optical method to monitor subcellular membrane potential in living cells, enabling precise and multiplexed imaging of organelle electrical activity.

bioRxiv · Mar 15, 2019Cell Biology