R. Rabadan

This study shows that radiation therapy promotes unsaturated fatty acid accumulation in glioblastoma, enhancing survival by reducing ER stress, and that targeting lipid metabolism could improve treatment outcomes.

This paper introduces a computational method to identify oncogenic mutations by integrating evolutionary information and protein structure prediction, demonstrating its effectiveness in pediatric leukemias.

This study compares the immune response in diffuse midline glioma after FLASH and conventional radiation using single-cell RNA sequencing and flow cytometry, finding differences in type 1 interferon signaling over time.

This study identifies cell-surface markers to isolate distinct cell types in ACC, shows myoepithelial-like cells as progenitors of ductal-like cells, and demonstrates RA signaling modulation as a therapeutic strategy.

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

This study identifies SF3B1 mutations causing anemia in MDS by inducing missplicing of MAP3K7, leading to reduced p38 MAPK activity and disrupted erythroid differentiation.

This paper identifies an ancestral recombination event in the RBD of SARS-CoV and SARS-CoV-2 that increased hACE2 binding affinity, suggesting SARS-like viruses may have pandemic potential.

This study identifies 38 candidate cancer-associated genes using topological data analysis integrated with somatic mutations and RNA expression data across 12 tumor types.

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.