Author

A. J. Carr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Approach:statistical model· 5 Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

S. G. Dakin· 5 shared B. Watkins· 3 shared K. Wheway· 3 shared A. H. Taylor· 2 shared B. Usukhbayar· 2 shared D. Beazley· 2 shared J. Rees· 2 shared J. Y. Mimpen· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersCancer Biology

S. G. Dakin

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

N. A. Jakobsen, S. Turkalj, A. G. X. Zeng, B. Stoilova, M. Metzner, M. S. Nagree, S. Shah, R. Moore, B. Usukhbayar, M. A. Salazar, G.-A. Gafencu, A. Kennedy, S. Newman, B. J. L. Kendrick, A. H. Taylor, , P. Vyas

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

bioRxiv · Sep 12, 2023 · PreprintCancer Biology

Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis

M. T. Ng, R. Borst, H. Gacaferi, S. Davidson, C. C. Machado, I. Reekie, M. Attar, D. Windell, M. Kurowska-Stolarska, L. MacDonald, S. Alivernini, M. Garvilles, K. Jansen, A. Bhalla, A. Lee, , S. G. Dakin

This study identifies MERTK+ macrophages and fibroblasts involved in resolving fibrosis in frozen shoulder using single-cell analysis and suggests therapeutic strategies to enhance their interaction.

bioRxiv · Jan 16, 2023 · PreprintCell Biology

Detecting and quantifying clonal selection in somatic stem cells

V. Korber, N. Ansari-Pour, N. A. Jakobsen, R. Moore, N. Claudino, M. Metzner, F. Horsch, B. Usukhbayar, M. A. Salazar, S. Newman, B. J. Kendrick, A. H. Taylor, R. Afinowi-Luitz, R. Gundle, B. Watkins, , T. Hofer

This study introduces SCIFER, a method to detect and quantify clonal selection in somatic stem cells, revealing accelerated stem cell division in clonal hematopoiesis.

bioRxiv · Dec 15, 2021Cancer Biology

Interleukin-17A causes osteoarthritis-like transcriptional changes in human osteoarthritis-derived chondrocytes and synovial fibroblasts in vitro

J. Y. Mimpen, M. J. Baldwin, A. P. Cribbs, M. Philpott, A. J. Carr, S. G. Dakin, S. J. B. Snelling

This study shows IL-17A induces OA-like gene expression in OA-derived chondrocytes and synovial fibroblasts, with secukinumab inhibiting these effects.

bioRxiv · Mar 5, 2021Immunology

In vitro evaluation of the response of human tendon-derived stromal cells to a novel electrospun suture for tendon repair

A. Nezhentsev, R. E. Abhari, M. J. Baldwin, J. Y. Mimpen, E. Augustyniak, M. Isaacs, P.-A. Mouthuy, A. J. Carr, S. J. Snelling

This study evaluates a novel electrospun suture's effect on human tendon-derived stromal cells, finding improved cell attachment and transcriptional response compared to PDS II.

bioRxiv · Nov 11, 2020Cell Biology

Proresolving mediators LXB4 and RvE1 regulate inflammation in stromal cells from patients with shoulder tendon tears

S. G. Dakin, R. A. Colas, K. Wheway, B. Watkins, L. Appleton, J. Rees, S. Gwilym, C. Little, J. Dalli, A. J. Carr

This study shows that proresolving mediators LXB4 and RvE1 modulate inflammation in tendon stromal cells from patients with shoulder tendon tears by altering lipid mediator profiles and inflammatory markers.

bioRxiv · Apr 11, 2019Cell Biology

Single-cell Map of Diverse Immune Phenotypes Driven by the Tumor Microenvironment

E. Azizi, A. J. Carr, G. Plitas, A. E. Cornish, C. Konopacki, S. Prabhakaran, J. Nainys, K. Wu, V. Kiseliovas, M. Setty, K. Choi, R. M. Fromme, P. Dao, P. T. McKenney, R. C. Wasti, , D. Pe'er

The paper maps immune cell phenotypes in breast cancer using single-cell RNA-seq and identifies continuous tumor-specific expansions driven by environmental cues.

bioRxiv · Apr 2, 2018Immunology