P. Vyas

Algorithmic construction of topologically complex biomineral lattices via cellular syncytia

This paper demonstrates how cellular syncytia control the growth of complex calcite ossicles through transport processes and cytoskeletal architecture.

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

The paper shows HDAC inhibitors induce AML cell differentiation via two distinct mechanisms: one through G1 arrest and another through G2 arrest via Aurora A and GSK3 inhibition.

The Role of Electron Spin, Chirality, and Charge Dynamics in Promoting thePersistence of Nascent Nucleic Acid-Peptide Complexes

This study shows how chirality and spin enhance protein-DNA complex stability through the chiral-induced spin selectivity effect.

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

Identification of a human hematopoietic stem cell subset that retains memory of inflammatory stress

The paper identifies a human HSC subset with inflammatory memory that accumulates with age and clonal hematopoiesis, potentially increasing cancer and infection risks.

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia.

This study shows that IDH2 mutations in AML block differentiation by altering H3K27 methylation, and that Enasidenib can reverse this block by modulating chromatin states.

Identification and Age-dependent Increase of Platelet Biased Human Hematopoietic Stem Cells

The paper identifies platelet-biased human hematopoietic stem cells (HSCs) and shows their proportion and transcriptional platelet priming increase with age.

Detecting and quantifying clonal selection in somatic stem cells

This study introduces SCIFER, a method to detect and quantify clonal selection in somatic stem cells, revealing accelerated stem cell division in clonal hematopoiesis.

Electrical signature of heterogeneous human mesenchymal stem cells

This study uses dielectrophoresis to quantify heterogeneity in human mesenchymal stem cells and links electrical properties to differentiation potential.

Dynamics of p53 DNA binding sites contributes to functional selectivity of p53-driven gene expression

This study shows that DNA flexibility of p53 response elements influences the timing and efficiency of p53-driven gene expression, affecting cellular responses to stress.

Integrative multi-omics identifies high risk Multiple Myeloma segment associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

The paper identifies a high-risk Multiple Myeloma subgroup using multi-omics data, linking genomic loss to dysregulated DNA repair and cell cycle pathways.

A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells

The paper identifies a novel tubulin-binding molecule that induces differentiation in AML cells, reducing tumour burden and improving survival in vivo.

Squid: Simplifying Quantitative Imaging Platform Development and Deployment

Squid provides an affordable, open-source imaging platform with modular hardware and software for deploying advanced microscopy techniques in research and low-resource settings.

A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells in vitro and shows anti-tumour effects in vivo

Leptospira surface protein LigA plays a multifaceted role in modulating the host innate immune response

This study identifies the LigA surface protein's A11 domain as a key factor in Leptospira's ability to modulate host immune responses and evade complement-mediated killing.

On the Emergence of P-Loop NTPase and Rossmann Enzymes from a Beta-Alpha-Beta Ancestral Fragment

This paper investigates the evolutionary relationship between P-loop NTPases and Rossmann enzymes, suggesting they may share a common ancestral beta-alpha-beta fragment.

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

This study identifies stage-specific differentiation delays caused by GATA1s in megakaryocytes, leading to increased immature cells and altered gene expression.