Author

L. Appleton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

A. A. Melcher· 1 shared A. Carr· 1 shared A. J. Carr· 1 shared A. Patrikeev· 1 shared A. R. Kendal· 1 shared B. Watkins· 1 shared C. Little· 1 shared C. Loizou· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. A. Melcher

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.

E. Armstrong, M. K. L. Chiu, S. Foo, L. Appleton, P. Nenclares, A. Patrikeev, N. Mohan, M. McLaughlin, G. Bozhanova, J. Hoebart, V. Roulstone, E. C. Patin, M. Pedersen, J. Kyula, F. Errington-Mais, , V. A. Jennings

This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.

bioRxiv · Apr 2, 2024Cancer Biology

Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomics

A. R. Kendal, T. Layton, H. Al-Mossawi, R. Brown, C. Loizou, M. Rogers, R. Sharp, S. Dakin, L. Appleton, A. Carr

This study identifies eight distinct human tendon cell populations in healthy and diseased tissue using single-cell CITE-sequencing, revealing disease-specific changes in cell composition and marker expression.

bioRxiv · Dec 9, 2019 · PreprintCell Biology

Proresolving mediators LXB4 and RvE1 regulate inflammation in stromal cells from patients with shoulder tendon tears

S. G. Dakin, R. A. Colas, K. Wheway, B. Watkins, L. Appleton, J. Rees, S. Gwilym, C. Little, J. Dalli, A. J. Carr

This study shows that proresolving mediators LXB4 and RvE1 modulate inflammation in tendon stromal cells from patients with shoulder tendon tears by altering lipid mediator profiles and inflammatory markers.

bioRxiv · Apr 11, 2019Cell Biology