The paper compares antigenic drift and viral fitness between two H1N1 clades, A5a.1 and A5a.2, finding that A5a.2 had reduced viral fitness despite similar or greater antigenic drift.

bioRxiv · Feb 26, 2023 · PreprintMicrobiology

Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal-macrophage interaction

E. H. Jung, Y.-D. Park, Q. Dragotakes, L. S. Ramirez, D. F. Smith, A. Dziedzic, P. R. Williamson, A. Jedlicka, A. Casadevall, C. Coelho

This study identifies fungal proteins released by Cryptococcus neoformans during macrophage infection, revealing their potential role in modulating virulence and host-pathogen interactions.

bioRxiv · Sep 21, 2021Microbiology

Progression and Resolution of SARS-1 CoV-2 Infection in Golden Syrian Hamsters

K. Mulka, S. Beck, C. Solis, A. Johanson, S. Queen, M. McCarron, M. Richardson, R. Zhou, P. Marinho, A. Jedlicka, S. Guerrero-Martin, E. Shirk, A. Braxton, J. Brockhurst, P. Creisher, , J. Mankowski

This study tracks SARS-CoV-2 infection progression in golden Syrian hamsters, showing weight loss, lung damage, and resolution over time.

bioRxiv · Jun 25, 2021Pathology

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

S. Dhakal, C. A. Ruiz-Bedoya, R. Zhou, P. Creisher, J. Villano, K. Littlefield, J. Castillo, P. Marinho, A. Jedlicka, A. Ordonez, N. Majewska, M. Betenbaugh, K. Flavahan, A. Mueller, M. Looney, , S. L. Klein

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

bioRxiv · Apr 2, 2021Microbiology