J. Castillo

Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.

GRAMD2+ alveolar type I cell plasticity facilitates cell state transitions in organoid culture

The paper identifies GRAMD2+ alveolar type I cells as plastic and capable of transitioning through multiple lung epithelial cell states in organoid culture.

LINC00261 expression reduces mutation accumulation while conferring resistance to cisplatin and altering the tumor-immune microenvironment in lung adenocarcinoma

This study identifies LINC00261 as a gene that reduces mutation accumulation, confers cisplatin resistance, and alters the tumor-immune microenvironment in lung adenocarcinoma.

An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis

This paper develops a DNA vaccine targeting dendritic cells that enhances isoniazid efficacy against tuberculosis by inducing strong immune responses and reducing Mtb burden.

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

Time varying connectivity across the brain changes as a function of nicotine abstinence state

This study examines changes in time-varying brain connectivity during nicotine abstinence and links these changes to clinical symptoms of nicotine withdrawal.