R. Cox

In vitro assays for clinical isolates of sequence type 131 Escherichia coli do not recapitulate in vivo infectivity using a murine model of urinary tract infection

This study shows in vitro assays poorly predict the in vivo infectivity of E. coli ST131 clinical isolates in a murine UTI model.

Influenza A virus resistance to 4-fluorouridine coincides with viral attenuation in vitro and in vivo

This study identifies mutations conferring resistance to 4-fluorouridine in influenza viruses and shows that resistant variants are attenuated in vivo and can be overcome by higher drug doses.

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

This study shows that prior respiratory virus infections worsen measles severity in ferrets and that antiviral treatment can mitigate immune amnesia and disease outcomes regardless of treatment timing.

Plant recognition by Trichoderma harzianum elicits upregulation of a novel secondary metabolite cluster required for colonization

This study identifies a novel gene cluster in Trichoderma harzianum that is upregulated during plant recognition and essential for fungal colonization.

Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets

This study compares the efficacy of paxlovid and molnupiravir in preventing SARS-CoV-2 transmission in ferrets, finding that molnupiravir reduces transmission while paxlovid does not.

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19

This study evaluates molnupiravir efficacy against SARS-CoV-2 variants in different models, finding VOC-dependent efficacy and sex-based differences in dwarf hamsters.

4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

This paper identifies 4'-Fluorouridine as an orally effective antiviral that inhibits RSV and SARS-CoV-2 replication in vivo.

Divergent epigenetic profiles from two differentially impacted wild populationsof estuarine cordgrass (Sporobolus alterniflorus)

This study examines how two populations of estuarine cordgrass show opposite DNA methylation patterns under heat stress, suggesting epigenetic mechanisms may enable rapid adaptation to urban environmental challenges.

Therapeutic Targeting of Measles Virus Polymerase with ERDRP-0519Suppresses All RNA Synthesis Activity

This paper characterizes ERDRP-0519, a small molecule inhibitor of measles virus polymerase, showing it blocks all RNA synthesis activity through a unique mechanism.

Twinfilin1 controls lamellipodial protrusive activity and actin turnover during vertebrate gastrulation

This study investigates the role of Twinfilin1 in actin dynamics during vertebrate gastrulation, linking it to lamellipodial protrusion and cell polarization.

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

The paper shows that inner and outer dynein arm subunits are partitioned into non-overlapping regions within DynAPs and identifies Daap1 as a novel regulator of ODA deployment.

Distributed alpha networks underlie individual differences in memory performance

The paper examines how individual differences in memory performance are linked to variations in distributed alpha networks measured via EEG.