A. Komarova

Recognition of copy-back defective interfering rabies virus genomes by RIG-I triggers the antiviral response against vaccine strains

This study shows that pathogenic RABV strains lack defective interfering genomes, leading to weak antiviral responses, while attenuated vaccine strains release 5cb DI genomes that enhance RIG-I-mediated IFN signaling and antiviral activity.

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.