H. Bourhy

Cell-type specific innate immune responses shape rabies virus tropism

This study investigates how cell-type specific innate immune responses influence rabies virus tropism by comparing susceptibility and antiviral responses in different CNS cell types.

Impact and mitigation of sampling bias to determine viral spread: evaluating discrete phylogeography through CTMC modeling and structured coalescent model approximations

This study evaluates how sampling bias affects viral spread inference using phylogeographic models and proposes strategies to mitigate its impact through simulation and empirical datasets.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

This study shows that hybrid immunity and vaccine boosters provide potent neutralizing activity against Omicron BA.1 and BA.2, while breakthrough infections induce nasal mucosal neutralization and identify an ultrapotent pan-variant antibody.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

Recognition of copy-back defective interfering rabies virus genomes by RIG-I triggers the antiviral response against vaccine strains

This study shows that pathogenic RABV strains lack defective interfering genomes, leading to weak antiviral responses, while attenuated vaccine strains release 5cb DI genomes that enhance RIG-I-mediated IFN signaling and antiviral activity.

Structure of the rabies virus glycoprotein trimer bound to a pre-fusion specific neutralizing antibody

The paper reports the cryo-EM structure of pre-fusion rabies virus glycoprotein bound to the neutralizing antibody RVA122, revealing its trimeric interface and stabilization mechanism.

Anti-COVID-19 efficacy of ivermectin in the golden hamster

This study evaluates ivermectin's efficacy against SARS-CoV-2 in golden hamsters, finding it reduces inflammation and neurological symptoms without affecting viral load.

SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance

This study shows SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance, potentially facilitating viral spread to the deeper lung.