Author

M. Chazal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:human· 7 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:multiple species· 1

Frequent Co-Authors

N. Jouvenet· 8 shared G. Beauclair· 3 shared O. Schwartz· 3 shared S.-M. Aicher· 3 shared F. Tangy· 2 shared J. Richardson· 2 shared M. Lemasson· 2 shared M. Sourisseau· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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8 shared papersMicrobiology

N. Jouvenet

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2

S. Gracias, M. Chazal, A. Decombe, Y. Unterfinger, A. Sogues, L. Pruvost, V. Robert, S. Lacour, M. Lemasson, M. Sourisseau, Z. Li, J. Richardson, E. Decroly, S. Pellegrini, V. Caval, N. Jouvenet

This study identifies a mechanism by which tick-borne flaviviruses inhibit interferon signaling by targeting TYK2 catalytic activity through their NS5 protein.

bioRxiv · Sep 7, 2023Microbiology

Integrated protein-protein interaction and RNA interference screens reveal novel restriction and dependency factors for a tick-borne flavivirus in its human host

M. Sourisseau, Y. Unterfinger, M. Lemasson, M. Chazal, S. Gracias, G. Caignard, F. Piumi, A. Grot, S. Moutailler, D. Vitour, N. Jouvenet, M. Coulpier, S. A. Lacour, J. Richardson

The paper identifies novel host proteins interacting with TBEV and characterizes their role as dependency or restriction factors using PPI screens and RNAi.

bioRxiv · Nov 3, 2022 · PreprintMicrobiology

Transcriptomic analysis of sorted lung cells revealed a proviral activity of the NF- κB pathway towards SARS-CoV-2

A. Bhargava, U. Szachnowski, M. Chazal, D. Foretek, S.-M. Aicher, J. Pipoli da Fonseca, P. Jeannin, G. Beauclair, M. Monot, A. Morillon, N. Jouvenet

The paper analyzes transcriptomic data from sorted SARS-CoV-2 infected lung cells to show the NF-κB pathway promotes viral replication while CYLD inhibits it.

bioRxiv · Feb 25, 2022Microbiology

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

S. Lesage, M. Chazal, G. Beauclair, D. Batalie, E. Couderc, A. Lescure, E. Del Nery, F. Tangy, A. Martin, N. Manel, n. jouvenet

The paper identifies twenty-one host genes that modulate flavivirus replication in an interferon-dependent manner using siRNA screening in ZIKV-infected microglial cells.

bioRxiv · Jul 20, 2021Microbiology

Species-specific molecular barriers to SARS-CoV-2 replication in bat cells

S.-M. Aicher, F. Streicher, M. Chazal, D. Planas, D. Luo, J. Buchrieser, M. Nemcova, V. Seidlova, J. Zukal, J. Serra-Cobo, D. Pontier, O. Schwartz, J. Pikula, L. Dacheux, N. Jouvenet

The paper investigates SARS-CoV-2 replication in bat cells and finds species-specific molecular barriers, with some cells controlling viral replication after human ACE2 expression.

bioRxiv · May 31, 2021Microbiology

Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen

A. Mac Kain, G. Maarifi, S.-M. Aicher, N. Arhel, A. Baidaliuk, S. Munier, F. Donati, T. Vallet, Q. D. Tran, A. Hardy, M. Chazal, F. Porrot, M. Ohainle, J. Carlson-Stevermer, J. Oki, , F. Roesch

The paper identifies DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen, showing it limits viral replication independently of SUMOylation.

bioRxiv · May 6, 2021Microbiology

The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the Golgi during viral infections

C. F. Daussy, S. C. Monard, C. Guy, S. Munoz-Gonzalez, M. Chazal, M. W. Anthonsen, n. jouvenet, T. Henry, M. - DREUX, E. F. Meurs, M. D. Hansen

The paper shows NLRP3 and ASC work with IRGM to rearrange the Golgi during viral infections like HCV and ZIKV.

bioRxiv · Apr 27, 2020Microbiology

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

N. Vabret, V. Najburg, A. Solovyov, P. Sulc, S. Balan, G. Beauclair, M. Chazal, H. Varet, R. Legendre, O. Sismeiro, R. Sanchez David, C. McClain, R. Gopal, L. Chauveau, O. Schwartz, , A. Komarova

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

bioRxiv · Sep 18, 2019Immunology