K.-A. McMahon

A role for caveolar proteins in regulation of the circadian clock

This study shows that cavin proteins modulate the circadian clock by interacting with PER2 and responding to stimuli like oxidative stress and calcium influx.

Dynamin2 stabilizes plasma membrane-connected caveolae by restraining fission

This study uses live-cell microscopy to show that Dyn2 stabilizes caveolae by preventing their fission, independent of its GTPase activity or EHD2.

Caveolae respond to acute oxidative stress through membrane lipid peroxidation, cytosolic release of CAVIN1, and downstream regulation of NRF2

This study shows that caveolae regulate oxidative stress response by lipid peroxidation, CAVIN1 release, and NRF2 interaction, affecting cell death and regeneration.

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

This study shows that Cavin1's intrinsically disordered domains are essential for caveola formation and trafficking through electrostatic interactions and phase separation.

In vivo proteomic mapping through GFP-directed proximity dependent biotin labelling in zebrafish

The paper introduces a method to map protein interactions in zebrafish using GFP-directed biotin labelling and applies it to study caveolin interactors in muscle cells.

Cavin3 released from caveolae interacts with BRCA1to regulate the cellular stress response

This study shows cavin3 interacts with BRCA1 to regulate DNA repair and cellular stress response, with implications for cancer.

Caveolae set levels of epithelial monolayer tension to eliminate tumor cells

The paper shows caveolae regulate epithelial tension through lipid signaling, enabling the elimination of oncogene-transformed cells by apical extrusion.