Author

A. L. Ferguson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Assay:DNA methylation· 2 Organism:human· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Tokmakoff· 2 shared B. Ashwood· 2 shared C. E. Palme· 2 shared E. Patrick· 2 shared J. H. Lee· 2 shared J. R. Clark· 2 shared J. R. Sachleben· 2 shared M. S. Jones· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

A. Tokmakoff

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatial mapping reveals unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers.

A. L. Ferguson, T. Beddow, E. Patrick, E. Willie, M. S. Elliott, T.-H. Low, J. Wykes, M. H. Hui, C. E. Palme, M. Boyer, J. R. Clark, J. H. Lee, U. Palendira, R. Gupta

The paper identifies immune landscape differences in responders and non-responders to anti-PD-1 therapy in head and neck cancers using spatial mapping.

bioRxiv · Apr 18, 2024 · PreprintCancer Biology

Molecular insight into how the position of an abasic site and its sequence environment influence DNA duplex stability and dynamics

B. Ashwood, M. S. Jones, Y. Lee, J. R. Sachleben, A. L. Ferguson, A. Tokmakoff

The paper examines how the position and sequence environment of an abasic site affect DNA duplex stability and dynamics using spectroscopy and simulations.

bioRxiv · Jul 22, 2023Biophysics

Data-driven discovery of innate immunomodulators via machine learning-guided high throughput screening

Y. Tang, J. Y. Kim, C. K. IP, A. Bahmani, Q. Chen, M. G. Rosenberger, A. P. Esser-Kahn, A. L. Ferguson

This study uses machine learning to guide high-throughput screening and discovers small molecules that modulate innate immune pathways, with some showing up to 15-fold suppression of NF-κB activity.

bioRxiv · Jun 26, 2023Immunology

Direct monitoring of the thermodynamics and kinetics of DNA and RNA dinucleotide dehybridization from gaps and overhangs

B. Ashwood, M. S. Jones, A. Radakovic, S. Khanna, Y. Lee, J. R. Sachleben, J. W. Szostak, A. L. Ferguson, A. Tokmakoff

This study measures the thermodynamics and kinetics of DNA and RNA dinucleotide dehybridization using infrared spectroscopy and simulations, revealing stabilization through stacking interactions and structural dynamics.

bioRxiv · Apr 10, 2023Biophysics

High-dimensional and spatial analysis reveals immune landscape dependent progression in cutaneous squamous cell carcinoma

A. L. Ferguson, A. R. Sharman, R. O. Allen, T. Ye, J. H. Lee, T.-H. H. Low, S. Ch'ng, C. E. Palme, B. Ashford, M. Ranson, j. R. Clark, E. Patrick, R. Gupta, U. Palendira

This study compares immune landscapes of non-progressing and progressing cutaneous squamous cell carcinomas to identify immune features associated with metastasis.

bioRxiv · Apr 19, 2022Pathology