A. L. Marston

Molecular basis for condensin enrichment at pericentromeres

This study identifies a molecular mechanism by which condensin is recruited to pericentromeres through a conserved interaction between Ycg1 and Sgo1, ensuring proper chromosome segregation.

Checkpoint-independent association of Mad3BUBR1 with Stu1CLASP directs homolog alignment in meiosis I

This study identifies a checkpoint-independent role for Mad3BUBR1 in promoting homolog alignment during meiosis I through its interaction with Stu1CLASP.

Rewiring of the phosphoproteome executes two meiotic divisions

The paper identifies how Spo13Meikin rewires the phosphoproteome through kinase activity to drive two meiotic divisions in budding yeast.

Age-dependent loss of cohesion protection in human oocytes

This study shows that loss of Sgo2 at the pericentromere bridge in aging human oocytes weakens sister chromatid cohesion, contributing to aneuploidy.

Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

The paper shows Eco1 acetylates Smc3 to form chromatin boundaries and cohesion in meiosis, essential for chromosome domain organization and segregation.

The proteomic landscape of centromeric chromatin reveals an essential role for the Ctf19CCAN complex in meiotic kinetochore assembly

The paper uses proteomics to identify meiosis-specific kinetochore remodelling and reveals the essential role of the Ctf19cCCAN complex in meiotic kinetochore assembly.

Evolutionary repair: changes in multiple functional modules allow meiotic cohesin to support mitosis

This study shows that evolving yeast to use meiosis-specific Rec8 in mitosis requires changes in transcriptional mediators and cell cycle regulators, not Rec8 itself, to improve sister chromosome cohesion.

SUMOylation targets shugoshin to stabilize sister kinetochore biorientation

This study identifies SUMOylation as a mechanism that stabilizes sister kinetochore biorientation by modulating Aurora B kinase and PP2A interactions.

Spo13 prevents premature cohesin cleavage during meiosis

This study shows that Spo13 prevents premature cohesin cleavage during meiosis I by blocking separase-dependent Rec8 loss at centromeres.

The Molecular Basis of Monopolin Recruitment to the Kinetochore

This paper identifies the molecular mechanisms by which the monopolin complex binds to the kinetochore protein Dsn1 in budding yeast, revealing two distinct binding motifs and their functional roles in meiosis I.