Author

A. Leppert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

A. Rising· 2 shared G. Chen· 2 shared J. Johansson· 2 shared M. Landreh· 2 shared A. Abelein· 1 shared A. Elofsson· 1 shared A. Fisahn· 1 shared B. M. Hallberg· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

A. Rising

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Controlling Drug Partitioning in Individual Protein Condensates through Laser-Induced Microscale Phase Transitions.

A. Leppert, F. Jianhui, V. Railaite, T. Bohn Pessatti, C. Morman, H. Osterholz, F. R. N. C. Maia, M. B. Linder, A. Rising, M. Landreh

This paper demonstrates laser-induced control of sol-gel transitions in protein condensates to enable drug loading.

bioRxiv · Mar 12, 2024 · PreprintBiophysics

A grappling hook interaction balances self-assembly and chaperone activity of Nucleophosmin 1

M. Saluri, A. Leppert, G. V. Gese, C. Sahin, D. Lama, M. Kaldmae, G. Chen, A. Elofsson, T. M. Allison, M. Arsenian-Henriksson, D. P. Lane, J. Johansson, B. M. Hallberg, M. Landreh

The paper investigates how NPM1 self-assembly and chaperone activity interact, finding that oligomerization modulates its ability to prevent amyloid formation.

bioRxiv · Sep 29, 2022 · PreprintBiophysics

Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue

G. Chen, Y. Andrade-Talavera, X. Zhong, S. Hassan, H. Biverstal, H. Poska, A. Abelein, A. Leppert, N. Kronqvist, A. Rising, H. Hebert, P. J.B. Koeck, A. Fisahn, J. Johansson

The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.

bioRxiv · Dec 1, 2021 · PreprintBiochemistry