Transmissibility of clinically relevant atovaquone-resistant Plasmodium falciparum by anopheline mosquitoes
V. A. Balta, D. Stiffler, A. Sayeed, A. K. Tripathi, R. Elahi, G. Mlambo, R. P. Bakshi, A. G. Dziedzic, A. E. Jedlicka, E. Nenortas, K. Romero-Rodriguez, M. A. Canonizado, A. Mann, A. Owen, D. J. Sullivan, , T. A. Shapiro
This study shows that atovaquone-resistant Plasmodium falciparum mutants have severe fitness costs in mosquitoes and fail to transmit to mice, reducing the risk of drug resistance spread.
bioRxiv · Feb 7, 2023Microbiology