Y. Bao

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Double-stranded RNA induces retinal pigment epithelium cell degeneration and inflammation

This study shows dsRNA triggers RIG-I signaling, leading to inflammation and RPE degeneration in AMD, with implications for pathogenesis.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

Genomic insights into photosymbiotic evolution in Tridacna squamosa

This study presents the first complete genome of Tridacna squamosa and integrates multi-omics data to uncover molecular mechanisms underlying photosymbiosis with dinoflagellates.

Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

Changes in the urine proteome after massage in healthy people

This study identifies changes in the urine proteome of healthy individuals after massage, finding more significant differences at 2h compared to 24h post-massage.

An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

This study defines an interconverting ensemble of ePEC states using cryo-EM and biochemical analysis, showing that ePECs occupy pre- or half-translocated states without always swiveling.

Time-varying Dynamic Network Model For Dynamic Resting State Functional Connectivity in fMRI and MEG imaging

This paper introduces a time-varying dynamic network model to analyze dynamic resting state functional connectivity in fMRI and MEG data, showing improved performance in capturing brain dynamics and detecting state transitions.

Void volume fraction of granular scaffolds

The paper provides simulated granular scaffolds with known void volume fraction (VVF) to study measurement accuracy and reveals VVF may be unreliable as a descriptor.

Genetic Diversity of Candidatus Liberibacter asiaticus Based on Four Hypervariable Genomic Regions in China

This study analyzes genetic diversity of Candidatus Liberibacter asiaticus in China using hypervariable genomic regions to understand strain differences and inform HLB control strategies.

Basis of narrow-spectrum activity of fidaxomicin on gut pathogen Clostridioides difficile

This study identifies the molecular basis of fidaxomicin's narrow-spectrum activity against Clostridioides difficile by analyzing its interaction with RNA polymerase.

Thinopyrum intermedium TiAP1 interacts with a chitin deacetylase from Blumeria graminis f. sp. tritici and increases the resistance to Bgt in wheat

This study identifies TiAP1 from Thinopyrum intermedium as a resistance gene against Blumeria graminis f. sp. tritici, showing it interacts with BgtCDA1 and enhances wheat resistance through immune activation.

Obligate movements of an active site-linked surface domain control RNA polymerase elongation and pausing via a Phe-pocket anchor

This paper investigates the dynamics of the SI3 insertion in E. coli RNA polymerase, showing it must move during transcription and that a Phe pocket modulates its function in elongation and pausing.

Post-translational knockdown and post-secretional modification of EsxA unambiguously determine the role of EsxA membrane permeabilizing activity in mycobacterial virulence

This study uses post-translational knockdown and post-secretional inhibition of EsxA to confirm its membrane-permeabilizing activity is essential for mycobacterial virulence without confounding genetic compensation effects.

Mycobacterial surface-associated ESX-1 virulence factors play a role in mycobacterial adherence and invasion into lung epithelial cells

This study shows EsxA is internalized into host cells and inserts into host membranes, and surface-associated EsxAB enhances mycobacterial adherence and invasion.

Three-dimensional Printing of Customized Bioresorbable Airway Stents

This paper develops bioresorbable airway stents using 3D printing and biomedical inks, showing biocompatibility and suitable degradation in rabbits.

Worldwide tracing of mutations and the evolutionary dynamics of SARS-CoV-2

The paper analyzes SARS-CoV-2 genome sequences to study mutation patterns and evolutionary dynamics, identifying mutations that may enhance viral fitness and provide insights for vaccine development.

An ABA Synthesis Enzyme Allele OsNCED2 Promotes the Aerobic Adaption in Upland Rice

This study identifies an OsNCED2 allele that enhances aerobic adaptation in upland rice by improving root development and drought tolerance through increased ABA synthesis.

Robotic Assay for Drought (RoAD): An Automated Phenotyping System for Brassinosteroid and Drought Response

The paper introduces RoAD, a robotic system for automated BR and drought response experiments in Arabidopsis and maize, using imaging and machine learning to measure plant traits.

The WD and linker domains of ATG16L1 required for non canonical autophagy limit lethal influenza A virus infection at epithelial surfaces.

This study shows that non-canonical autophagy, mediated by the WD and linker domains of ATG16L1, protects against lethal influenza A virus infection by limiting viral replication and inflammation in airway epithelial cells.

Discovery of genes encoding a Streptolysin S-like toxin biosynthetic cluster in a select highly pathogenic methicillin resistant Staphylococcus aureus JKD6159 strain

The paper identifies a Streptolysin S-like toxin biosynthetic cluster in a highly pathogenic MRSA strain and investigates its potential role through genetic and phenotypic assays.

An investigation of PS-b-PEO polymersomes for the oral treatment and diagnosis of hyperammonemia

This paper investigates polymersomes for oral treatment and diagnosis of hyperammonemia, finding they do not reduce ammonia levels in rats but can detect ammonia via pH changes.

A novel deep learning scheme for morphology-based classification of mycobacterial infection in unstained macrophages

This paper develops a deep learning scheme to classify M. marinum-infected and uninfected macrophages based on morphology, achieving high accuracy at early infection stages.

The Landscape Of Type VI Secretion Across Human Gut Microbiomes Reveals Its Role In Community Composition

The paper characterizes the distribution of type VI secretion systems in human gut microbiomes and links their presence to community composition changes.