A. L. Mosley

Unraveling Systemic Responses to NQO1-Activated IB-DNQand Rucaparib Single and Dual Agent Therapy in Triple-Negative Breast Cancers

This study evaluates the effects of IB-DNQ and Rucaparib on TNBC cells, revealing synergistic effects and novel protein biophysical changes via thermal proteome profiling.

Gemcitabine plus nab-paclitaxel preserves skeletal and cardiac mass and function in a murine model of pancreatic cancer cachexia

This study shows that gemcitabine plus nab-paclitaxel reduces tumor burden and prevents muscle and cardiac wasting in a murine model of pancreatic cancer cachexia.

Mechanisms of spinophilin-dependent pancreas dysregulation underlying diabesity

This study investigates spinophilin's role in obesity-related pancreatic dysfunction and glucose homeostasis using Spino-/- mice, showing improved glucose tolerance and pancreatic beta cell function.

Obtaining Increased Functional Proteomics Insights from Thermal Proteome Profiling through Optimized Melt Shift Calculation and Statistical Analysis

This study improves the InflectSSP pipeline for Thermal Proteome Profiling to enhance sensitivity and specificity in detecting proteome changes, demonstrating its effectiveness through reanalysis of datasets and a new UPR study.

Asparagine starvation suppresses histone demethylation through iron depletion

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

Quantitative proteomic and metabolomic profiling reveals altered mitochondrial metabolism and folate biosynthesis pathways in the aging Drosophila eye

This study identifies age-related changes in mitochondrial metabolism and folate biosynthesis in Drosophila eyes using proteomic and metabolomic profiling, linking these changes to immune activation and potential neuroprotective strategies.

Boosting detection of low abundance proteins in thermal proteome profiling experiments by addition of an isobaric trigger channel to TMT multiplexes

The paper introduces an isobaric trigger channel in TMT multiplexes to improve detection of low abundance proteins in thermal proteome profiling, enhancing detection of CPF subunits without affecting Tm calculations.