Author

A. Nolan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. P. O'Gara· 2 shared M. S. Zeden· 2 shared A. Atreja· 1 shared A. Castillo· 1 shared A. Di Narzo· 1 shared A. Grinspan· 1 shared A. Gründling· 1 shared A. Hurley· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

J. P. O'Gara

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3 papers

Recent·Most cited

Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

M. S. Zeden, L. A. Gallagher, E. Bueno, A. Nolan, J. Ahm, D. Shinde, F. Razvi, M. Sladek, O. Burke, E. O'Neill, P. D. Fey, F. Cava, V. C. Thomas, J. P. O'Gara

This study shows that mutating the pentose phosphate pathway gene pgl in MRSA increases resistance to beta-lactam antibiotics through metabolic reprogramming and changes in cell envelope precursors.

bioRxiv · Mar 3, 2023 · PreprintMicrobiology

Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics

A. Nolan, M. S. Zeden, C. Campbell, I. Kviatkovski, L. Urwin, R. M. Corrigan, A. Gründling, J. P. O'Gara

This study shows that purine nucleosides like guanosine and xanthosine reduce β-lactam resistance in MRSA by lowering c-di-AMP levels, acting as adjuvants to restore antibiotic effectiveness.

bioRxiv · Sep 1, 2022 · PreprintMicrobiology

Gut microbiota density influences host physiology and is shaped by host and microbial factors

E. J. Contijoch, G. J. Britton, C. Yang, I. Mogno, Z. Li, R. Ng, S. R. Llewellyn, S. Hira, C. Johnson, K. M. Rabinowitz, R. Barkan, I. Dotan, R. P. Hirten, S.-C. Fu, Y. Luo, , C

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.

bioRxiv · Jul 12, 2018Microbiology