Author

A. Tighe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

S. S. Taylor· 3 shared J. McGrail· 2 shared L. Nelson· 2 shared A. Nussenzweig· 1 shared B. Barnes· 1 shared D. Bronder· 1 shared D. Hirsch· 1 shared D. Perera· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

S. S. Taylor

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3 papers

Recent·Most cited

TP53 loss initiates chromosomal instability in high-grade serous ovarian cancer

D. Bronder, D. Wangsa, D. Zong, T. J. Meyer, R. Wardenaar, P. Minshall, A. Tighe, D. Hirsch, K. Heselmeyer-Haddad, L. Nelson, D. Spierings, J. C. McGrail, M. Cam, A. Nussenzweig, F. Foijer, , S. S. Taylor

This study shows that TP53 loss in fallopian tube epithelial cells drives chromosomal instability through cell cycle deregulation, without requiring additional mutations.

bioRxiv · Mar 12, 2021Cancer Biology

Classification of ovarian cancer cell lines using transcriptional profiles defines the five major pathological subtypes

B. Barnes, L. Nelson, A. Tighe, R. Morgan, J. McGrail, S. S. Taylor

This paper classifies ovarian cancer cell lines into five subtypes using transcriptional profiles, aligning with known pathological subtypes and providing a method for future classification.

bioRxiv · Jul 14, 2020 · PreprintCancer Biology

Inhibitors of the Bub1 spindle assembly checkpoint kinase: Synthesis of BAY-320 and comparison with 2OH-BNPP1

I. Amalina, H. Whalley, D. Perera, J. McGrail, A. Tighe, D. Procter, S. S. Taylor

This study compares two Bub1 kinase inhibitors, finding that BAY-320 inhibits Bub1 in vivo but with high concentrations and potential off-target effects, while 2OH-BNPP1 is ineffective.

bioRxiv · Jul 2, 2020Cell Biology