Transglutaminase 2 associated with PI3K and PTEN in a putative membrane-bound signalosome platform blunts cell death
K. Jambrovics, P. Boto, Z. Kolostyak, S. Zsolt, A. Pap, I. Szatmari, Z. Czimmerer, I. P. Uray, L. Fesus, Z. Balajthy
This study shows that TG2 promotes cell survival in APL cells by forming a signalosome platform that hyperactivates PI3K and inhibits PTEN, reducing apoptosis.
bioRxiv · Feb 16, 2022 · PreprintCancer Biology