Author

A. R. Pearson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

B. A. Yorke· 2 shared D. von Stetten· 2 shared A. Chari· 1 shared A. Chretien· 1 shared A. Dickmanns· 1 shared A. Mancuso· 1 shared A. Round· 1 shared A. Wrona· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

B. A. Yorke

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Light-induced Trpin/Metout switching during BLUF domain activation in ATP-bound photoactivatable adenylate cyclase OaPAC

A. Chretien, M. F. Nagel, S. Botha, R. de Wijn, L. Brings, K. Doerner, H. Han, J. C. P. Koliyadu, R. Letrun, A. Round, T. Sato, C. Schmidt, R.-C. Secareanu, D. von Stetten, M. Vakili, , R. Schubert

This study investigates the light-induced structural changes in OaPAC's BLUF domain, revealing a Trpin/Metout transition and conformational shifts during ATP activation.

bioRxiv · Sep 5, 2023Biochemistry

An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin.

J. A. Hill, Y. R. Nyathi, S. Horrell, D. von Stetten, D. Axford, R. L. Owen, G. S. Beddard, A. R. Pearson, H. M. Ginn, B. A. Yorke

The paper identifies a UV-induced redox switch mechanism in human gamma-D crystallin that may rescue oxidative damage.

bioRxiv · Aug 25, 2023Biochemistry

Redox regulation of the SARS-CoV-2 main protease provides new opportunities for drug design

K. Tittmann, L.-M. Funk, G. Poschmann, A. Chari, F. Rabe von Pappenheim, K. M. Stegmann, A. Dickmanns, N. Eulig, M. Wensien, E. Paknia, G. Heyne, E. Penka, A. R. Pearson, C. Berndt, T. Fritz, , U. Curth

This study identifies redox regulation of SARS-CoV-2 Mpro and discovers antiviral reagents that mimic redox switching, suggesting new drug targets.

bioRxiv · Apr 18, 2022 · PreprintBiochemistry

Diffusive dynamics of Aspartate α-decarboxylase (ADC) liganded with D-serine in aqueous solution

T. Raskar, S. Niebling, J. M. Devos, B. A. Yorke, M. Härtlein, N. Huse, T. V. Forsyth, T. Seydel, A. R. Pearson

This study investigates how ligand binding affects the diffusive dynamics and oligomerization of E. coli ADC using neutron spectroscopy, dynamic light scattering, and molecular dynamics simulations.

bioRxiv · Aug 11, 2020 · PreprintBiophysics