Author

A. Round

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:structural biology· 4 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

H. Han· 4 shared J. Schulz· 4 shared M. Vakili· 4 shared A. Wrona· 3 shared C. Kim· 3 shared C. Schmidt· 3 shared R. Bean· 3 shared R. de Wijn· 3 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

H. Han

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

D. Doppler, A. Grieco, D. Koh, A. Manna, A. Ansari, R. Alvarez, K. Karpos, H. Le, M. Sonker, G. Ketawala, S. Mahmud, I. Quereda Moraleda, A. L. Pey, R. Letrun, K. Doerner, , A. Ros

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

bioRxiv · Apr 29, 2024Biochemistry

Crystal structure of a bacterial photoactivated adenylate cyclase determined at room temperature by serial femtosecond crystallography

S. M. Kapetanaki, N. Coquelle, D. von Stetten, M. Byrdin, R. Rios-Santacruz, R. Bean, J. Bielecki, M. Boudjelida, Z. Fekete, G. W. Grime, H. Han, C. Hatton, S. Kantamneni, K. Kharitonov, C. Kim, , M. Weik

The paper determines the crystal structure of a bacterial photoactivated adenylate cyclase at room temperature using serial femtosecond crystallography and compares it with cryo structures to study structural changes upon light exposure.

bioRxiv · Apr 21, 2024 · PreprintBiophysics

Light-induced Trpin/Metout switching during BLUF domain activation in ATP-bound photoactivatable adenylate cyclase OaPAC

A. Chretien, M. F. Nagel, S. Botha, R. de Wijn, L. Brings, K. Doerner, H. Han, J. C. P. Koliyadu, R. Letrun, A. Round, T. Sato, C. Schmidt, R.-C. Secareanu, D. von Stetten, M. Vakili, , R. Schubert

This study investigates the light-induced structural changes in OaPAC's BLUF domain, revealing a Trpin/Metout transition and conformational shifts during ATP activation.

bioRxiv · Sep 5, 2023Biochemistry

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

M. Vakili, H. Han, C. Schmidt, A. Wrona, M. Kloos, I. de Diego, K. Dorner, T. Geng, C. Kim, F. Koua, D. Melo, M. Rappas, A. Round, E. Round, M. Sikorski, , J. Schulz

This paper introduces a mix-and-extrude method for time-resolved protein crystallography using 3D printed microchannels to study ligand-induced reactions in viscous media.

bioRxiv · Nov 23, 2022Biochemistry

Architecture of TAF11/TAF13/TBP complex suggests novel regulatory state in General Transcription Factor TFIID function

K. Gupta, A. A. Watson, T. Baptista, E. Scheer, A. L. Chambers, C. Koehler, J. Zou, I. Obong-Ebong, E. Kandiah, A. Temblador, A. Round, E. Forest, P. Man, C. Bieniossek, E. D. Laue, , I. Berger

The paper identifies a ternary TAF11/TAF13/TBP complex and reveals a novel regulatory state in TFIID function through structural and biochemical analyses.

bioRxiv · Jul 26, 2017Biochemistry