Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects
W. He, Q. Luo, J. Zhao, M. Wang, L. Feng, A. Zhao, A. Reda, E. Lindgren, J.-B. Strukenborg, J. Chen, Q. Deng
This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.
bioRxiv · Jun 25, 2024 · PreprintCell Biology