Q. Luo

A smartphone-based genetically recombinant whole-cell biosensor for highly sensitive monitoring of polychlorinated biphenyls (PCBs)

This paper develops a genetically engineered whole-cell biosensor using E. coli to detect multiple PCB congeners with high sensitivity, and integrates it with a smartphone for real-time monitoring.

Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects

This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.

Transcriptomic Profile of Lin-Sca1+c-kit (LSK) cells in db/db mice with long-standing diabetes

This study examines the transcriptomic changes in LSK cells of db/db mice with chronic diabetes, identifying 2076 mRNAs and 35 miRNAs, including two novel miRNAs, and links these changes to inflammation and neurovascular deficits.

Targetable leukemia dependency on noncanonical PI3Kγ signaling

This study identifies a targetable dependency on noncanonical PI3Kγ signaling in acute leukemias, showing that PI3Kγ inhibition with eganelisib improves survival when combined with cytarabine.

Why is there so much variability in crop multi-model studies?

The paper investigates variability in crop model studies and finds parameter uncertainty contributes more than twice as much as structural uncertainty to total variability.

m6A Demethylase FTO Stabilizes LINK-A to Exert Oncogenic Roles via MCM3-Mediated Cell Cycle Progression and HIF-1α Activation

This study shows FTO stabilizes LINK-A, promoting ESCC progression through MCM3-mediated cell cycle progression and HIF-1α activation.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity

This study identifies HCP5 as a key antiapoptotic factor in ESCC by preventing UTP3 degradation and activating c-Myc to suppress apoptosis.

Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control

The paper compares exercise and antioxidant intervention in type 2 diabetic rats, showing both improve blood glucose via hepatic AMPK activation and redox balance, with exercise promoting moderate ROS for AMPK activation.

DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Confers Chemoresistance via Activation of YAP Signaling

This study identifies D-AS2 as a noncoding RNA that promotes chemoresistance in SCC by activating YAP signaling through the PLD/PA axis, and shows that targeting D-AS2 sensitizes SCC to cisplatin.

Hypoxia Dynamically Regulates DBC1 Ubiquitination and Stability by SIAH2 and OTUD5 in Breast Cancer Progression

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

Mosaic Evolution of Beta Barrel Porin Encoding Genes in Escherichia coli

The paper identifies mosaic evolution in multiple beta-barrel porin genes in E. coli, showing local recombination and sequence variation that may help bacteria evade environmental threats.

All-optical mechanobiology interrogation of YAP in human cancer and normal cells using a novel multi-functional system

This paper introduces an integrated system for automated multi-functional imaging and analysis to study YAP mechanosensitivity in human cells.

Automatic Multi-functional Integration Program (AMFIP) towards All-optical Mechanobiology Interrogation

AMFIP enables automatic multi-functional live-cell imaging by integrating hardware and software without extra costs or hardware, demonstrating its utility in mechanobiology studies.

New metabolic alterations and predictive marker pipecolic acid in sera for esophageal squamous cell carcinoma

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

Reconciling Inherent Interfacial Compatibility Conflict Enhances Adhesive Infiltration and Resolves Dentin Bonding Durability

This paper identifies interfacial compatibility conflict as the cause of poor dentin bonding durability and shows that hydrophobizing the demineralized dentin matrix enhances adhesive infiltration and bonding strength.

Contribution of climate models and APSIM phenological parameters to uncertainties in spring wheat simulations: application of SUFI-2 algorithm in northeast Australia

The paper calibrates a wheat model using SUFI-2 and evaluates climate model uncertainties on spring wheat simulations in Australia.

Overexpression of EiKCS confers paraquat-tolerance in rice (Oryza sativa L.) by promoting polyamine pathway

Overexpressing EiKCS from goosegrass in rice increases polyamine levels and enhances paraquat tolerance through improved antioxidant capacity and photosynthesis.

ORMDL1 is upregulated and associated with favorable outcome in colorectal cancer

This study shows ORMDL1 is upregulated in colorectal cancer and associated with better patient survival.

Alisertib exerts KRAS allele specific anticancer effects in colorectal cancer

This study investigates how Alisertib affects KRAS mutations in colorectal cancer cells, showing allele-specific effects on RAS signaling and cell death mechanisms.

Roles of Signaling Compounds and WRKY31 in the Defense of Pinus massoniana L. Against Dendrolimus punctatus

This study investigates the role of WRKY31 and signaling compounds in enhancing insect resistance in Pinus massoniana L. against Dendrolimus punctatus by modulating hormone signaling pathways.

The chaos in calibrating crop models

The paper proposes a method to develop calibration guidelines for system models by analyzing multi-model simulations, applying it to crop model phenology calibration and providing recommendations on objective functions, parameters, and software.

Genome-Wide Mapping of Cisplatin Damaged Gene Loci

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

Multi-model evaluation of phenology prediction for wheat in Australia

This study evaluates wheat phenology prediction models in Australia, finding that multi-model averaging performs nearly as well as the best single model, with an average error of 9 days.

Structural insight into outer membrane asymmetry maintenance of Gram-negative bacteria by the phospholipid transporter MlaFEDB

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

How well do crop modeling groups predict wheat phenology, given calibration data from the target population?

This study evaluates how well 27 crop modeling groups predict wheat phenology in Northern France using calibration data from the same target population, finding mean absolute errors comparable to measurement error.

Schisandrin B for treatment of male infertility

This study identifies Schisandrin B as a potential treatment for male infertility by improving sperm count, mobility, and reproductive ability in a mouse model.

MACS: Rapid aqueous clearing system for three-dimensional mapping of intact organs

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.