L. Feng

Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects

This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.

Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Identification of avaC from infant gut microbial isolates that convert 5AVA to 2-piperidone with high efficiency

This study identifies gut bacterial strains and the gene avaC that efficiently convert 5AVA to 2-piperidone, with implications for disease risk prediction and industrial biosynthesis.

mRNA Vaccines Encoding Influenza Virus Hemagglutinin (HA) Elicits Immunity in Mice from Influenza A Virus Challenge

This study shows mRNA vaccines encoding influenza HA proteins protect mice against influenza challenge, eliciting neutralizing antibodies and reducing viral titers.

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

This study shows intermittent fasting increases IL-22 production by intestinal ILC3s, promoting beigeing of white adipose tissue and improving metabolic health.

Elucidating the role of water in collagen self assembly by isotopically modulating collagen hydration

This study investigates how water isotopes affect collagen self-assembly by comparing D2O and H2O, finding faster assembly and thinner fibrils in D2O due to reduced hydration.

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

Pathogen protein modularity enables elaborate mimicry of a host phosphatase

The paper identifies a modular (L)WY-LWY motif in Phytophthora effectors that recruits host PP2A phosphatase, enabling phosphoprotein regulation through structural mimicry.

Cell type-specific responses to fungal infection in plants revealed by single-cell transcriptomics

This study uses single-cell transcriptomics to reveal cell type-specific responses to fungal infection in Arabidopsis thaliana, identifying gene expression patterns and defense mechanisms.

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

Tumour Extracellular Vesicles Induce Neutrophil Extracellular Traps To Promote Lymph Node Metastasis

This study shows that tumor-derived extracellular vesicles induce neutrophil extracellular traps in lymph nodes, promoting metastasis and identifying potential therapeutic targets.

Does the territorial behaviour of the Amur tiger affect the accuracy of occupancy estimation?

This study develops a modified occupancy model to distinguish true-presence from pseudo-presence in Amur tigers, improving occupancy estimation accuracy by accounting for territorial behavior.

A Mitochondrial Inside-Out Iron-Calcium Signal Reveals Drug Targets for Parkinsons Disease

This study identifies a mitochondrial iron-calcium signaling mechanism in Parkinson's disease and discovers drug targets using Miro1-based screens and genetic analysis.

The protist ubiquitin ligase effector PbE3-2 targets RD21A to impede plant immunity

This study identifies PbE3-2, a protist effector that degrades RD21A to suppress plant immunity, contributing to clubroot disease.

Toxicity of microplastics and plastic additive co-exposure in liver Disse organoids from healthy donors and patient-derived induced pluripotent stem cells

This study uses hiPSC-derived organoids to show that co-exposure to microplastics and TBBPA increases toxicity in patient-derived organoids compared to healthy ones.

Retrotransposons facilitate tissue-specific horizontal Transfer of circulating tumor DNA

This study shows retrotransposons enable tissue-specific horizontal gene transfer of circulating tumor DNA in cancer cells, influencing treatment response and opening new therapeutic avenues.

FIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

The effector protein CgNLP1 of Colletotrichum gloeosporioides from Hevea brasiliensis disrupts nuclear localization of necrosis-induced transcription factor HbMYB8-like to suppress plant defense signaling

Encoding sensing functions into material interface for a rationally engineered integrated electrochemical liquid biopsy

This paper develops an integrated electrochemical liquid biopsy platform for detecting cancer exosomes from blood using a rational engineering strategy.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

The paper shows TRPV4 activates TMEM16F in trophoblasts, promoting cell fusion, and identifies this as a mechanism for syncytialization and disease-related fusion.

Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan

The paper identifies the biosynthetic pathway of nemamides in C. elegans, revealing a novel mechanism for intermediate trafficking between PKS and NRPS systems.

Single-molecule mechanical unfolding kinetics of unmodified Saccharomyces cerevisiae tRNAPhe: a hint to the tRNA chaperone-tRNA interaction mechanism

This study uses optical tweezers and molecular dynamics to analyze the mechanical unfolding kinetics of yeast tRNAphe, revealing how structural features influence folding and the role of tertiary interactions in unfolding cooperativity.

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

In situ 3D comparison of Chlorella pyrenoidosa with nuclear-irradiated mutagenic strains by using focused ion beam milling and cryo-electron tomography

This study uses cryo-electron tomography to compare 3D subcellular structures of wild-type and mutagenic Chlorella pyrenoidosa strains, revealing structural changes linked to increased growth rates.

Light intensity affects the coloration and structure of chimeric leaves of Ananas comosus var. bracteatus

This study investigates how light intensity affects the coloration and structure of chimeric leaves in Ananas comosus var. bracteatus, finding that 50% shade optimizes growth and ornamental value.