A. S. Arbab

This study shows MDSC-derived exosomes suppress CD8 T-cells and promote tumor growth by modulating immunosuppression and inflammation in the tumor microenvironment.

This study investigates changes in the tumor microenvironment (TME) in response to different therapies in a glioblastoma model, finding that TME-targeting therapies improve survival.

This study develops exosomes targeting M2-macrophages for detecting and depleting them, showing reduced tumor burden and improved survival in a breast cancer model.

This study shows that vaccinating MMTV-PyMT mice with GT198 protein delays tumor growth and reduces metastasis, suggesting a shared tumorigenic pathway between human and mouse cancers.

The paper shows differential in vivo distribution of 131I-labeled exosomes from different cell sources and links this to their protein content, with implications for theranostic applications.