Author

A. Sharkey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Moffett· 3 shared A. Appios· 2 shared F. Colucci· 2 shared N. McGovern· 2 shared R. S. Hamilton· 2 shared X. X. Zhao· 2 shared B. Liu· 1 shared C. Lee· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

A. Moffett

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4 papers

Recent·Most cited

Human HLFneg placental erythro-myeloid progenitors give rise to HLA Class IIneg Hofbauer cells

J. R. Thomas, A. Appios, E. F. Calderbank, X. X. Zhao, R. S. Hamilton, A. Moffett, A. Sharkey, E. Laurenti, N. McGovern

The paper identifies placental erythro-myeloid progenitors (PEMPs) that generate Hofbauer cells, showing human primitive haematopoiesis occurs in the placenta, not just the yolk sac.

bioRxiv · Feb 26, 2022 · PreprintImmunology

Phenotypic and functional characterisation of first trimester human placental macrophages, Hofbauer cells.

J. Thomas, A. Appios, X. X. Zhao, R. A. Dutkiewicz, M. J. Donde, C. Lee, P. M. Naidu, C. Lee, J. Cerveira, B. Liu, F. Ginhoux, G. Burton, R. S. Hamilton, A. Moffett, A. Sharkey, N. McGovern

The paper characterizes first trimester human placental macrophages, identifying Hofbauer cells as HLA-DR-FOLR2+ macrophages with microbicidal properties and secreted factors influencing placental angiogenesis.

bioRxiv · Sep 3, 2020Immunology

High-resolution genetic and phenotypic analysis of KIR2DL1 alleles and their association with pre-eclampsia

O. Huhn, O. Chazara, M. Ivarsson, C. Retiere, T. Venkatesan, H. Ghadially, A. Moffett, A. Sharkey, F. Colucci

The paper develops a method to distinguish KIR2DL1A and KIR2DL1B alleles in NK cells and shows KIR2DL1A is associated with increased pre-eclampsia risk.

bioRxiv · May 25, 2018Immunology

Molecular definition of group 1 innate lymphoid cells in the mouse uterus

I. Filipovic, L. Chiossone, P. Vacca, R. Hamilton, T. Ingegnere, J.-M. Doisne, D. A. Hawkes, M. C. Mingari, A. Sharkey, L. Moretta, F. Colucci

This study defines the molecular characteristics of group 1 innate lymphoid cells in the mouse uterus, identifying distinct subsets with specific functions during pregnancy.

bioRxiv · May 24, 2018Immunology