BiochemistrybioRxivPreprint
Energy deficit-independent stress response in the Frataxin-depleted heart: evidence that Integrated Stress Response can predominate over mTORC1 activation
C. Vasquez, M. Patel, A. Sivaramakrishnan…·E. L. Seifert
This study shows that in FXN-depleted hearts, the integrated stress response (ISR) predominates over mTORC1 activation, despite reduced energy production, suggesting a protective mechanism.
DOI 10.1101/2020.06.12.148361