J. Cox

HAF Prevents Hepatocyte Apoptosis and Hepatocellular Carcinoma through Transcriptional Regulation of the NF-κB pathway.

Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma

This study uses isotope tracing to show that β-catenin mutations in HCC suppress phosphatidylcholine synthesis while increasing fatty acid oxidation.

Enamel proteins reveal biological sex and genetic variability within southern African Paranthropus

This study uses enamel proteomics to determine biological sex and assess intraspecific variation in Paranthropus robustus from South Africa, supporting the idea that morphological variation may reflect taxonomic diversity.

Design and validation of an exposure system for efficient inter-animal SARS-CoV-2 airborne transmission in Syrian hamsters

This paper designs and validates an exposure system for efficient SARS-CoV-2 airborne transmission in Syrian hamsters, showing similar virological outcomes between 1:1 and 1:4 infected-to-naive ratios.

CD200R1 promotes IL-17 production by ILC3s, by enhancing STAT3 activation

This study shows CD200R1 promotes IL-17 production by ILC3s through STAT3 activation, and its deficiency reduces psoriasis severity.

Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages

The paper introduces pSCoPE, a single-cell proteomics method that improves sensitivity, completeness, and depth, enabling analysis of protein variation in macrophages.

Trade-Offs Between Hepatic Host Defense and Metabolic Programs Underlie Sex-Biased Diseases

This study identifies a sex-dependent trade-off between hepatic host defense and metabolic programs in mice, showing that BCL6 protects males from infection but increases metabolic disease risk under dietary excess.

Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors

The paper shows that serine palmitoyltransferase (SPT) modulates intestinal stem cell homeostasis by promoting stemness through sphingolipid production and PPAR-alpha activation, linking diet to cancer risk.

Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism

This study shows that mitochondrial fatty acid synthesis (mtFAS) regulates electron transport chain (ETC) complexes and skeletal myoblast differentiation, linking fatty acid synthesis to oxidative metabolism.

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

This study shows that mitochondrial pyruvate carrier is essential for optimal brown fat thermogenesis, as its deletion impairs cold adaptation and alters metabolic pathways.

Local human movement patterns and land use impact exposure to zoonotic malaria in Malaysian Borneo

The paper quantifies how human movement and land use patterns affect exposure to zoonotic malaria in Malaysian Borneo using GPS tracking and ecological modeling.

A spatial genomic approach identifies time lags and historic barriers to gene flow in a rapidly fragmenting Appalachian landscape

This study uses spatial genomic analysis to identify historical barriers to gene flow in copperhead snakes, finding genetic structuring aligned with a historic highway and suggesting time lags in genetic effects.

LIN28B-PDZ Binding Kinase Signaling Promotes Neuroblastoma Metastasis

This study identifies LIN28B's role in promoting neuroblastoma metastasis through the regulation of PBK, a kinase that enhances self-renewal and migration.

Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice Guidelines

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.

Performance of an IAVI-African Network of Clinical Research Laboratories in Standardized ELISpot and Peripheral Blood Mononuclear Cell Processing in Support of HIV Vaccine Clinical Trials

The paper evaluates the performance of seven GCLP-accredited laboratories in standardized ELISpot and PBMC processing over four years, showing high consistency and reliability in data generation.

Spatial Capture-Recapture for Categorically Marked Populations with An Application to Genetic Capture-Recapture

The paper introduces a categorical spatial partial identity model (SPIM) to improve density estimation in populations with uncertain individual identity, showing it performs better than existing methods in high uncertainty scenarios.

EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification

EASI-tag enables accurate multiplexed proteome quantification by generating interference-free reporter ions through dissociation at low collision energy.

Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.