Author

D. Perera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 1 Ecology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Hahs· 1 shared A. McLean· 1 shared A. R. Venkitaraman· 1 shared A. Tighe· 1 shared A. Venkitaraman· 1 shared B. Lee· 1 shared C. Firth· 1 shared C. Frezza· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperEcology

A. Hahs

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A transcriptional response to replication stress selectively expands a subset of BRCA2-mutant mammary epithelial cells

M. Ghaderi Najafabadi, G. K. Gray, L. R. Kong, K. Gupta, D. Perera, J. S. Brugge, A. Venkitaraman, M. Shehata

The paper shows that BRCA2-mutant mammary epithelial cells with low hormone receptor expression expand under replication stress through a transcriptional response involving Tspan8 and Thrsp.

bioRxiv · Nov 14, 2022 · PreprintCancer Biology

Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia

M. Petruzzelli, M. Ferrer, M. Schuijs, Z. Hall, D. Perera, S. Raghunathan, M. Vacca, E. Gaude, M. J. Lukey, D. I. Jodrell, C. Frezza, E. F. Wagner, T. Janowitz, T. Y. F. Halim, A. R. Venkitaraman

The paper shows that early neutrophilia driven by aerobic glycolysis supports host metabolism and delays cancer cachexia in murine models.

bioRxiv · Aug 11, 2021Cancer Biology

Rats in the city: implications for zoonotic disease risk in an urbanizing world

K. R. Blasdell, S. Morand, S. G. W. Laurance, S. L. Doggett, A. Hahs, D. Perera, C. Firth

This study examines how urbanization affects zoonotic disease risk by analyzing changes in rodent abundance, ectoparasite vectors, and microbial pathogens in Malaysian Borneo.

bioRxiv · Mar 18, 2021 · PreprintEcology

Mechanisms underlying proximity between oral commensal bacteria

D. Perera, A. McLean, V. Morillo Lopez, K. Cloutier-Leblanc, E. Almeida, K. Cabana, J. L. Mark Welch, M. M. Ramsey

The paper investigates interactions between Haemophilus parainfluenzae and Streptococcus mitis in the oral microbiome, revealing density-dependent co-occurrence and metabolic dependencies.

bioRxiv · Sep 29, 2020 · PreprintMicrobiology

Inhibitors of the Bub1 spindle assembly checkpoint kinase: Synthesis of BAY-320 and comparison with 2OH-BNPP1

I. Amalina, H. Whalley, D. Perera, J. McGrail, A. Tighe, D. Procter, S. S. Taylor

This study compares two Bub1 kinase inhibitors, finding that BAY-320 inhibits Bub1 in vivo but with high concentrations and potential off-target effects, while 2OH-BNPP1 is ineffective.

bioRxiv · Jul 2, 2020Cell Biology

TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection

S. N. Amrun, J. J. Tan, N. Y. Rickett, J. A. Cox, B. Lee, M. J. Griffiths, T. Solomon, D. Perera, M. H. Ooi, J. A. Hiscox, L. F. Ng

The paper investigates EV71 infection in human cells, identifies TREM-1 activation as a key driver of severe disease, and shows its role in inflammation and viral load.

bioRxiv · Jun 27, 2019Immunology