Cancer BiologybioRxiv
TP53 loss initiates chromosomal instability in high-grade serous ovarian cancer
D. Bronder, D. Wangsa, D. Zong…·S. S. Taylor
This study shows that TP53 loss in fallopian tube epithelial cells drives chromosomal instability through cell cycle deregulation, without requiring additional mutations.
DOI 10.1242/dmm.049001