Author

L. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Tighe· 2 shared B. Barnes· 2 shared J. McGrail· 2 shared R. Morgan· 2 shared S. S. Taylor· 2 shared A. Nussenzweig· 1 shared C. Coulson-Gilmer· 1 shared D. Bronder· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

A. Tighe

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Author profile →

3 papers

Recent·Most cited

TP53 loss initiates chromosomal instability in high-grade serous ovarian cancer

D. Bronder, D. Wangsa, D. Zong, T. J. Meyer, R. Wardenaar, P. Minshall, A. Tighe, D. Hirsch, K. Heselmeyer-Haddad, L. Nelson, D. Spierings, J. C. McGrail, M. Cam, A. Nussenzweig, F. Foijer, , S. S. Taylor

This study shows that TP53 loss in fallopian tube epithelial cells drives chromosomal instability through cell cycle deregulation, without requiring additional mutations.

bioRxiv · Mar 12, 2021Cancer Biology

Classification of ovarian cancer cell lines using transcriptional profiles defines the five major pathological subtypes

B. Barnes, L. Nelson, A. Tighe, R. Morgan, J. McGrail, S. S. Taylor

This paper classifies ovarian cancer cell lines into five subtypes using transcriptional profiles, aligning with known pathological subtypes and providing a method for future classification.

bioRxiv · Jul 14, 2020 · PreprintCancer Biology

PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes

C. Coulson-Gilmer, R. Morgan, L. Nelson, B. Barnes, J. McGrail, S. Taylor

This study shows that PARG inhibition causes replication catastrophe in some ovarian cancer cells with down-regulated DNA replication genes, suggesting a potential biomarker for PARG inhibitor response.

bioRxiv · Jul 13, 2020 · PreprintCancer Biology