Author

D. Kent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. C. Wilkinson· 2 shared A. Cagan· 1 shared A. Clay· 1 shared A. G. X. Zeng· 1 shared A. K. Fielding· 1 shared A. M. Syanda· 1 shared A. N. Holding· 1 shared A. S. Mason· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

A. C. Wilkinson

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Author profile →

5 papers

Recent·Most cited

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

D. Kealy, R. Ellerington, S. Bansal, A. G. X. Zeng, J. J. F. Medeiros, K. A. West, N.-M. Blacknell, C. A. Hawley, J. Lukaszonek, R. Gawne, H. M. Khoo, G. Caalim, B. Drylie, J. Chatzigerou, B. Rodriguez Lima Ferreira, , K. S. Bridge

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

bioRxiv · Jul 2, 2024 · PreprintCancer Biology

The long-term effects of chemotherapy on normal blood cells

E. Mitchell, M. H. Pham, A. Clay, R. Sanghvi, S. Pietsch, J. I. Hsu, H. Jung, A. Vedi, S. Moody, J. Wang, D. Leonganmornlert, M. Spencer Chapman, N. Williams, E. Dunstone, A. Santarsieri, , M. R. Stratton

This study examines the long-term effects of chemotherapy on normal blood cells by analyzing mutation burdens and cell population structure in treated individuals.

bioRxiv · May 20, 2024Cell Biology

A Single Cell Cloning Platform for Gene Edited Functional Murine Hematopoietic Stem Cells

H. J. Becker, R. Ishida, A. C. Wilkinson, T. Kimura, M. S. J. Lee, C. Coban, Y. Ota, A. Tojo, D. Kent, S. Yamazaki

The paper presents a method to expand and profile genetically edited murine hematopoietic stem cells at clonal density to reduce genetic heterogeneity before transplantation.

bioRxiv · Mar 23, 2022 · PreprintCell Biology

Small molecule screen employing patient-derived iPS hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency

D. Kent, S. S. Ng, P. Khoshkenar, A. M. Syanda, L. Chao Zheng, M. Zieger, C. Greer, S. B. Hatch, J. M. Segal, S. J. I. Blackford, V. Chowdary, T. Ismali, D. Danovi, S. Sahdeo, D. Ebner, , S. T. Rashid

A small molecule screen in patient iPSCs with in vivo validation in mice identifies LRRK2 as a new therapeutic target for Alpha-1 Antitrypsin Deficiency.

bioRxiv · Sep 17, 2021 · PreprintCell Biology

Developmental tuning of mineralization drives morphological diversity of gill cover bones in sculpins and their relatives

E. G. Cytrynbaum, C. M. Small, R. Y. Kwon, B. Hung, D. Kent, Y.-l. Yan, M. L. Knope, R. A. Bremiller, T. Desvignes, C. B. Kimmel

The paper investigates how developmental regulation of bone mineralization contributes to morphological diversity in gill cover bones of sculpins and their relatives.

bioRxiv · Oct 8, 2018Evolutionary Biology