Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling
M. Pawlak, D. DeTomaso, G. Meyer zu Horste, Y. Lee, J. Nyman, D. Dionne, C. Wang, A. Wallrapp, P. R. Burkett, S. J. Riesenfeld, A. C. Anderson, A. Regev, R. J. Xavier, N. Yosef, V. K. Kuchroo
This study shows IL-23R signaling enables Th1 cells to acquire a colitogenic phenotype, distinct from Th17 cells, and identifies CD160 as a key regulator.
bioRxiv · Jan 24, 2021 · PreprintImmunology