D. Dionne

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

The paper develops a cross-tissue single-nucleus RNA-seq atlas to identify cell types and gene functions in health and disease.

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling

This study shows IL-23R signaling enables Th1 cells to acquire a colitogenic phenotype, distinct from Th17 cells, and identifies CD160 as a key regulator.

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.

Skin inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors

The paper shows that psoriasis is driven by the reprogramming of quiescent skin-resident ILCs into pathogenic effectors through epigenetic and transcriptional changes.