Author

A. Watts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. J. Costa-Filho· 3 shared J. M. van den Elsen· 2 shared M. R. B. Batista· 2 shared P. J. Judge· 2 shared A. C. Darby· 1 shared A. Campbell· 1 shared A. Clark· 1 shared A. D. Pandya· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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3 shared papersBiophysics

A. J. Costa-Filho

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Timing and Delivery route effects of Cecal Microbiome transplants on Salmonella Typhimurium infections in Chickens

S. Pottenger, A. Watts, A. Wedley, S. Jopson, A. C. Darby, P. Wigley

This study shows that cecal microbiome transplants given to chicks between 4 and 72 hours after hatching reduce Salmonella Typhimurium shedding and colonization, with no significant difference in effectiveness based on administration route.

bioRxiv · Aug 8, 2022 · PreprintMicrobiology

In vivo amyloid-like fibrils produced under stress

N. A. Fontana, A. D. Rosse, A. Watts, P. S. R. Coelho, A. J. Costa-Filho

This study detects amyloid-like fibrils in vivo using autofluorescence from β-sheets, showing Grh1's role in stress responses without extrinsic probes.

bioRxiv · Feb 2, 2021 · PreprintBiophysics

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

M. Malimova, E.-H. Sidhom, A. Satyam, M. Dvela-Levitt, M. Melanson, B. T. Chamberlain, S. L. Alper, J. Santos, J. Gutierrez, A. Subramanian, E. Grinkevich, E. R. Bricio, C. Kim, A. Clark, A. Watts, , A. Greka

The paper identifies Fostamatinib as a potential repurposing drug for acute lung injury by reducing MUC1 protein levels in preclinical models.

Cell Reports Medicine · Nov 1, 2020Peer-reviewedCell Biology

Physicochemical characterization, toxicity and in vivo biodistribution studies of a discoidal, lipid-based drug delivery vehicle: Lipodisq nanoparticles containing doxorubicin

M. L. Torgersen, P. J. Judge, J. F. Bada Juarez, A. D. Pandya, M. Fusser, C. W. Davies, M. K. Maciejewska, D. J. Yin, G. M. Maelandsmo, T. Skotland, A. Watts, K. Sandvig

This paper evaluates Lipodisq nanoparticles as drug delivery vehicles, showing their cytotoxicity and in vivo biodistribution of doxorubicin and their components.

bioRxiv · Jun 18, 2020Pharmacology & Toxicology

Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift

M. Knight, R. Woolley, A. Kwok, S. Parsons, H. Jones, C. Gulacsy, P. Phaal, O. Kassaar, K. Dawkins, E. Rodriguez, A. Marques, L. Bowsher, S. A. Wells, A. Watts, J. M. van den Elsen, , C. R. Pudney

This paper demonstrates that quantifying the fluorescence red edge excitation shift (REES) can sensitively monitor monoclonal antibody stability across timeframes and concentrations.

bioRxiv · Mar 23, 2020Biochemistry

Conformational flexibility of GRASP protein and its constituent PDZ subdomains reveals structural basis of its promiscuous interactome

L. F. S. Mendes, M. R. B. Batista, P. J. Judge, A. Watts, C. Redfield, A. J. Costa-Filho

This paper investigates the structural flexibility of GRASP PDZ domains and explains their promiscuous interactome through biophysical analysis.

bioRxiv · Jun 10, 2019Biophysics

Exploring Conformational Transitions and Free Energy Profiles of Proton Coupled Oligopeptide Transporters

M. R. B. Batista, A. Watts, A. J. Costa-Filho

This study uses molecular dynamics simulations to analyze conformational transitions and free energy profiles of PepTst, revealing how protonation and ligand binding influence the transporter's mechanism.

bioRxiv · May 28, 2019Biophysics

Utilisation of staphylococcal immune evasion protein Sbi as a novel vaccine adjuvant

Y. Yang, C. Back, M. Graewert, A. Wahid, H. Denton, R. Kildani, J. Paulin, K. Woerner, W. Kaiser, D. I. Svergun, A. Sartbaeva, A. Watts, K. Marchbank, J. M. van den Elsen

This paper demonstrates that the Staphylococcal protein Sbi can be used as a vaccine adjuvant by promoting natural opsonisation of antigens with C3 fragments, enhancing immune responses.

bioRxiv · Sep 10, 2018Biochemistry