S. Parsons

mTOR signaling controls the formation of smooth muscle cell-derived intimal fibroblasts during vasculitis.

This study identifies mTOR signaling as essential for the formation of SMC-derived intimal fibroblasts in vasculitis, offering a therapeutic target for vascular remodeling.

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

Towards a General Approach for Bat Echolocation Detection and Classification

This paper introduces BatDetect2, a deep learning pipeline for detecting and classifying bat echolocation calls, showing improved performance across diverse regions and species.

Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift

This paper demonstrates that quantifying the fluorescence red edge excitation shift (REES) can sensitively monitor monoclonal antibody stability across timeframes and concentrations.

The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancer

The paper identifies eight resistance mechanisms to CDK4/6 inhibitors in HR+ breast cancer, present in 80% of resistant tumors, with potential therapeutic strategies.

Bat Detective - Deep Learning Tools for Bat Acoustic Signal Detection

This paper develops and evaluates open-source deep learning tools for detecting bat echolocation calls in noisy audio recordings, showing improved performance over existing methods.