A. Zloza

Attenuated Dengue Virus PV001-DV Induces Oncolytic Cell Death and Potent Anti-Tumor Immunity

This study shows that PV001-DV, an attenuated Dengue virus, induces oncolytic cell death and activates anti-tumor immunity in melanoma and breast cancer cells.

Inactivated SARS-CoV-2 Reprograms the Tumor Immune Microenvironment and Improves Murine Cancer Outcomes

This study shows that inactivated SARS-CoV-2 converts immunologically cold tumors to hot by generating CD8+ T cells, improving cancer outcomes in melanoma and triple-negative breast cancer.

Overriding defective FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in diabetic wound

The paper identifies impaired FPR1 chemotaxis signaling in diabetic neutrophils as a cause of infection vulnerability and shows that CCL3 can override this defect to improve infection control and healing.

Redefining colorectal cancer classification and clinical stratification through a single-cell atlas

This paper constructs a single-cell transcriptome atlas of colorectal cancer to reveal subclonal heterogeneity and identify CAF subtypes associated with survival and immunotherapy resistance.

Acyclovir Improves the Efficacy of Chemoradiation in Nasopharyngeal Cancer Containing the Epstein Barr Virus Genome

This study shows that adding acyclovir to chemoradiation reduces viability of EBV-infected NPC cells by increasing TK and apoptosis markers.

Immunobiochemical reconstruction of influenza lung infection - Melanoma skin cancer interactions

The paper develops a mechanistic immunobiochemical model to explain how influenza infection promotes melanoma growth by analyzing T cell receptor signaling and gene regulatory networks.