B. A. Duerkop

The paper identifies a phage protein that inhibits type IV restriction enzymes in drug-resistant enterococci, revealing how phages evolve to overcome bacterial defense mechanisms.

This study shows that aging increases gut microbial virulence, contributing to more severe sepsis in older adults.

This study uses IS-Seq to show that phage infection and antibiotic exposure drive IS256 diversification in enterococci, linking selective pressures to genome evolution.

This study shows that genetically distinct bacteriophages induce unique genomic changes in Enterococcus faecalis, highlighting phage-specific host responses during evolution.

The paper identifies differential intestinal bacteriophage communities in individuals at risk for RA based on anti-CCP status, linking them to distinct metabolic potentials and potential roles in RA pathogenesis.

This study shows that phage infection and sub-lethal antibiotics trigger T7SS in Enterococcus faecalis, inhibiting bystander bacteria through cell contact.

This study identifies cell wall-associated molecules that confer phage resistance in E. faecium and shows that phage resistance mutations enhance antibiotic susceptibility and synergize with antimicrobials.

This study identifies bacterial factors important for Enterococcus faecalis vaginal colonization and persistence using a transposon mutagenesis screen in a mouse model.

This paper introduces a sequencing-based method called transductomics to detect and analyze ongoing horizontal gene transfer in microbial communities and pure cultures.

The paper uses genomic approaches to study how Enterococcus faecalis responds to phage infection, identifying transcriptional regulators and gene expression changes that influence bacterial fitness and community interactions.

This paper develops CRISPR-Cas antimicrobials delivered via conjugative plasmids to selectively remove antibiotic resistance genes from Enterococcus faecalis in vitro and in mice.

This study shows that phage resistance in enterococci reduces their intestinal colonization ability and antibiotic sensitivity, suggesting phage therapy could complement antibiotics in treating dysbiotic microbiota.