A. Nath

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

Oxysterol accumulation in aging cells alters GPCR signalling

This study shows that oxysterol accumulation in aged cells disrupts CXCR4 signaling by altering G-protein coupling specificity.

Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.

Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein (FABP1) and FABP1 Binding Alters Drug Metabolism

This study shows drugs form ternary complexes with human FABP1 and that FABP1 binding alters drug metabolism by affecting CYP2C9 activity.

ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

This study shows that combining ONC201/TIC10 with everolimus improves therapeutic response in metastatic ER+ breast cancer by targeting mitochondrial function and oxidative phosphorylation.

Declining old pole physiology gradually enhances gene expression asymmetry in bacteria

The paper shows that aging in bacterial mother cells leads to declining gene expression in old poles, increasing phenotypic heterogeneity across generations.

Cancer cells communicate with macrophages to prevent T cell activation during development of cell cycle therapy resistance

The paper shows cancer cells in resistant tumors promote immune-suppressive macrophages, reducing T-cell activation, and suggests balancing cell cycle inhibition with immune activation for better therapy.

Imbalanced immune response and dysregulation of neural functions underline fatal opportunistic encephalitis caused by astrovirus

This study investigates astrovirus-induced CNS infection in immunocompromised patients, showing immune dysregulation and neural dysfunction similar to HIV.

Probing Interactions of Therapeutic Antibodies with Serum via Second Virial Coefficient Measurements

This paper measures the second virial coefficient of therapeutic antibodies in undiluted serum using fluorescence correlation spectroscopy to understand how biological environments affect protein interactions.

Antimicrobial peptide induced-stress renders Staphylococcus aureus susceptible to toxic nucleoside analogues

The paper shows that sub-lethal concentrations of the antimicrobial peptide pexiganan increase susceptibility of Staphylococcus aureus to nucleoside analogues.

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

The paper integrates gene expression and sarcomere organization in hiPSC-derived cardiomyocytes to predict subcellular states and reveal correlations between transcript abundance and structural patterns.

A 'one-two punch' therapy strategy to target chemoresistance in estrogen receptor positive breast cancer

This study identifies a sequential therapy strategy using HDAC inhibitors to reverse chemotherapy-induced resistance in ER+ breast cancer by targeting cancer stem cell-like traits.

Rapid formation of peptide/lipid co-aggregates by the amyloidogenic seminal peptide PAP248-286

This paper shows that the seminal peptide PAP248-286 forms peptide/lipid co-aggregates called messicles, which assemble faster and under different conditions than amyloid fibrils.

Identification of a novel tedizolid resistance mutation in rpoB of methicillin-resistant Staphylococcus aureus

The paper identifies a novel rpoB mutation in MRSA associated with tedizolid resistance and reports cross-resistance to other antibiotics.

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of \"quasi-ordered\" states.

This study characterizes the disordered N-terminal region of HSPB1 using hybrid methods, revealing quasi-ordered states and their role in HSPB1 function and disease.