Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia
C. Paiboonrungruang, Z. Xiong, D. Lamson, Y. Li, B. Bowman, J. Chembo, C. Huang, J. Li, E. W. Livingston, J. E. Frank, V. Chen, Y. Li, B. Weissman, H. Yuan, K. P. Williams, , X. Chen
This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.
Redox Biology · Nov 1, 2023Peer-reviewedCancer Biology