B. Chackerian

An integrated signaling threshold initiates IgG response towards virus-like immunogens

The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.

A Virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in Non-Human Primates

A bivalent PCSK9 vaccine using virus-like particles reduces LDL-cholesterol in non-human primates without statins, showing vaccine efficacy in cholesterol management.

Minimal determinants for lifelong antiviral antibody responses in BALB/c mice from a single exposure to virus-like immunogens at low doses

This study shows that a single low-dose injection of virus-like immunogens induces lifelong neutralizing antibodies in mice, highlighting key determinants for durable antiviral immunity.

A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

This study shows that a vaccine targeting the L9 epitope of CSP in Plasmodium falciparum provides protection against blood-stage malaria in mice.

A VLP-based vaccine targeting ANGPTL3 lowers plasma triglycerides in mice

This paper develops ANGPTL3-targeting VLP vaccines that lower plasma triglycerides in mice by enhancing lipoprotein lipase activity.

Virus-Like Particle Based-Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

This study develops VLP-based vaccines targeting the HIV-1 FP8 epitope, showing they induce high-titer FP8-specific antibodies and effective neutralizing responses in mice.

An Epitope-based Malaria Vaccine Targeting the Junctional Domain of Circumsporozoite Protein

This paper develops a malaria vaccine targeting the CIS43 epitope on CSP using Qβ VLPs, showing high immunogenicity and partial protection in mice and macaques.