M. Jia

High Resolution Salmonella Subtyping by the MLSTnext Method

The paper introduces a high-resolution Salmonella subtyping method using MLSTnext-NGS, which efficiently identifies serovars and resolves mixed strains in food samples.

Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry

This study uses native mass spectrometry and molecular dynamics to show how intrinsically disordered CTDs in Hfq form a network that integrates RNA contacts and stabilizes the hexamer.

Intermittent fasting mitigates cognitive deficits in Alzheimer's disease via the gut-brain axis

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

Dynamic Expedition of Leading Mutations in SARS-CoV-2 Spike Glycoproteins

The paper introduces a time-resolved statistical method to analyze the evolutionary dynamics of SARS-CoV-2 spike mutations and quantifies mutation strength using the L-index.

A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

Myofibroblast transcriptome indicates SFRP2+ fibroblast progenitors in systemic sclerosis skin

The paper identifies SFRP2+ fibroblast progenitors as the source of myofibroblasts in systemic sclerosis skin using single-cell RNA sequencing.

Furanoditerpenoid biosynthesis in the bioenergy crop switchgrass is catalyzed by an alternate metabolic pathway

This study identifies and characterizes five cytochrome P450 monooxygenases in switchgrass that catalyze an alternative pathway for furanoditerpenoid biosynthesis, bypassing the canonical class I diterpene synthase pathway.

Structural Characteristics and Proton Conductivity of the Gel Within the Electrosensory Organs of Cartilaginous Fishes

This study describes the structural characteristics and proton conductivity of gel in cartilaginous fish electrosensory organs using microscopy, x-ray scattering, and enzymatic digestion.

Sex-specific predictive values of biomarkers for immunotherapy efficacy in lung adenocarcinoma

This study identifies sex-specific differences in the predictive power of biomarkers for anti-PD-1 immunotherapy efficacy in lung adenocarcinoma, highlighting the need to consider sex when using conventional biomarkers.

Virus-Like Particle Based-Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

This study develops VLP-based vaccines targeting the HIV-1 FP8 epitope, showing they induce high-titer FP8-specific antibodies and effective neutralizing responses in mice.

Sex-based mutational landscape confers sensitivity to checkpoint blockade immunotherapy in cutaneous melanoma

The paper investigates sex-based differences in the mutational landscape of cutaneous melanoma and their impact on response to anti-PD-1 immunotherapy, finding that high tumor mutation burden correlates with immunotherapeutic response only in males.

Elucidating the competition between heterotrophic denitrification and DNRA using the resource-ratio theory

This study uses resource-ratio theory to analyze competition between denitrification and DNRA, revealing how COD/N ratio and other factors influence microbial competition outcomes in continuous cultures.

Proton Conductivity of Glycosaminoglycans

The paper measures proton conductivity of glycosaminoglycans and finds it correlates with their chemical structure, confirming a structure-property relationship.