Increased TCR signaling in regulatory T cells is disengaged from TCR affinity
Y. Jing, Y. Kong, D. Allard, B. Liu, E. Kolawole, M. Sprouse, B. Evavold, M. Bettini, M. Bettini
The paper compares TCR repertoires of regulatory and effector T cells in non-obese diabetic mice, showing similar reactivity but differing suppressive capacity linked to TCR affinity.
bioRxiv · Jan 17, 2023 · PreprintImmunology