F. Han

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

Mechanism of ozone alleviation of malignant ascites in hepatocellular carcinoma through inhibition of NETs

This study shows ozone reduces malignant ascites in hepatocellular carcinoma by inhibiting NETs through AMPK activation and SR-A mediated phagocytosis of DAMPs.

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

This study shows that SARS-CoV-2 boosting induces GC B cell responses and that Omicron-based vaccines can elicit novel epitope-specific antibodies despite antigenic imprinting.

A new species of Nanhsiungchelys (Testudines: Cryptodira: Nanhsiungchelyidae) from the Upper Cretaceous of Nanxiong Basin, China, and the role of anterolateral processes on the carapace in drag reduction

The paper describes a new turtle species and investigates the function of carapace anterolateral processes using computational fluid dynamics.

Shell Microelectrode Arrays (MEAs) for brain organoids

This paper develops shell microelectrode arrays (MEAs) for brain organoids, enabling long-term electrophysiology recording from 3D organoids.

The specific roles of renal macrophages in monitoring and clearing off intratubular particles

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

Characteristics of N6-methyladenosine modification during sexual reproduction of Chlamydomonas reinhardtii

This study identifies m6A modification patterns and functions during sexual reproduction in Chlamydomonas reinhardtii, showing its role in regulating microtubule-based processes.

Computed tomographic analysis of the dental system of three Jurassic ceratopsians: implications for the evolution of the tooth replacement pattern and diet in early-diverging ceratopsians

This study uses CT scans to analyze the dental systems of three Jurassic ceratopsians, revealing tooth replacement patterns and dietary strategies that inform their evolution.

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

This paper describes a monoclonal antibody, DZIF-10c, that effectively neutralizes SARS-CoV-2 and its variants when administered intranasally to mice, offering potential for topical treatment.

The genetic architecture underlying ecological adaptation in Atlantic herring is not consistent with the infinitesimal model

The study identifies hundreds of loci associated with ecological adaptation in Atlantic herring, finding that allele frequency shifts at these loci contradict the infinitesimal model for complex traits.

Proto-sex locus in large yellow croaker provides insights into early evolution of the sex chromosome

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

Remodeling gut microbiota by Streptococcus thermophilus 19 attenuates inflammation in septic mice

This study shows that S. thermophilus 19 reduces inflammation in septic mice by remodeling gut microbiota.

Hsa_circ_0001947 suppresses acute myeloid leukemia progression by sponging hsa-miR-329-5p and regulating CREBRF expression

This study identifies hsa_circ_0001947 as a tumor suppressor in AML that inhibits cell proliferation and drug resistance by sponging hsa-miR-329-5p and regulating CREBRF expression.