Nanopore sequencing methods detect cell-free DNA associated with minimal residual disease and central nervous system infiltration in pediatric Acute Lymphoblastic Leukemia
S. Sampathi, Y. Chernyavskaya, M. Haney, L. H. Moore, I. Snyder, A. Cox, T. Taylor, B. Fuller, T. Badgett, J. Blackburn
This paper develops a nanopore sequencing method to detect B-ALL-associated cell-free DNA in blood and CSF, enabling early detection of MRD and CNS infiltration in pediatric ALL patients.
bioRxiv · Sep 27, 2021 · PreprintCancer Biology