D. J. Odde

Cell migration simulator-based biomarkers for glioblastoma

This paper develops a physics-based cell migration simulator to identify physical biomarkers for glioblastoma, linking mechanical parameters to transcriptomic data and drug response.

Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds

This study identifies that T cells achieve maximal migration speeds by combining bleb formation with adhesion-based forces, challenging the feasibility of adhesion-free migration.

Glioblastoma cells use an integrin- and CD44-mediated motor-clutch mode of migration in brain tissue

This study identifies a motor-clutch mechanism for glioblastoma cell migration in brain tissue, highlighting the roles of integrins, CD44, and myosin motors.

Optimality of motor and clutch mechanical properties in a generalized model for cell traction forces

This study analyzes the mechanical properties of cell traction forces using a motor-clutch model, identifying optimal substrate and clutch stiffness for maximal force transmission and revealing how cell adhesion and actomyosin activity influence migration.

RAD-TGTs: Measurement of cellular tensions via flow cytometry and DNA sequencing enabled by force-dependent rupture and delivery of DNA tension probes

The paper introduces RAD-TGTs, a method to measure cellular tensions using DNA duplexes that rupture under force, with readout via flow cytometry and DNA sequencing.

Differential migration mechanics and immune responses of glioblastoma subtypes

This study shows mesenchymal glioblastoma cells migrate faster and generate more traction force than proneural cells, but their immunologically hot environment improves survival despite aggressive growth.

Clinically Validated Model Predicts the Effect of Intratumoral Heterogeneity on Overall Survival for Non-Small Cell Lung Cancer (NSCLC) Patients

The paper develops a model to predict the impact of intratumoral heterogeneity on survival in NSCLC patients using radiation dose schedules and gene expression data.

Tau avoids the GTP cap at growing microtubule plus ends

This paper shows that tau preferentially binds GDP-tubulin over GTP-tubulin, causing it to lag behind microtubule plus-ends and suppress shortening rather than promote growth.

Negative durotaxis: cell movement toward softer environments

The paper identifies negative durotaxis, where cells migrate toward softer environments, and shows that integrin adhesion and motor-clutch dynamics drive this behavior in glioblastoma and neurites.

Poisson poisoning as the mechanism of action of the microtubule-targeting agent colchicine

This study identifies colchicine's mechanism as Poisson poisoning of microtubule ends, revealing it acts as a true kinetic stabilizer through low-affinity binding and time-dependent effects.

Atomistic basis of microtubule dynamic instability assessed via multiscale modeling

The paper uses multiscale modeling to show that GTP hydrolysis in microtubules causes bond weakening and bending, driving dynamic instability and tip structures observed in microscopy.

Multi-scale Computational Modeling of Tubulin-Tubulin Lateral Interaction

This study uses multi-scale modeling to show that lateral tubulin interactions are not the main driver of microtubule dynamic instability, linking atomistic simulations to cellular behavior.

Regulation and dynamics of force transmission at individual cell-matrix adhesion bonds

The paper uses fluorescent molecular tension sensors to study force transmission by integrins in living cells, revealing functional modularity and a revised model for mechanical homeostasis.

Glioma cell migration in confined microchannels via a motor-clutch mechanism

This study investigates glioma cell migration in confined microchannels using a motor-clutch mechanism, showing that parameters from 2D experiments predict 1D migration behaviors.